How do changes in the brain happen because of Alzheimer's disease?

Key changes in the brain in AD include:

- Brain shrinkage. This is called atrophy.

- The loss of nerve cells

- The presence of neuritic amyloid plaques (protein deposits that collect between nerve cells, or neurons)

- The presence of neurofibrillary tangles (twisted fibers in the nerve cells, thought to contribute to cell breakdown)

- Brain inflammation (swelling)