mind sicknessthe hippocampus: which allows control conduct and self-manage, 3. the orbitofrontal cortex: which is involved in preparing and evaluation making. troubles with these regions of the brain may well contribute to indications of borderline personality disorder. The development of these parts of the brain is influenced by your early childhood. These parts of your brain are also accountable for emotional state regulation, which may explain some of the problems people with borderline personality disorder have in close interactions. Environmental elements of the borderline personality disorder: a number of environmental factors seem to be well-known and widespread among people with borderline personality disorder. These comprise: 1. being a victim of emotional, physical or sex-related mistreatment, 2. being exposed to chronic terror or frustration as a child, 3. being abandoned by one or both parents, 4. growing up with another relatives member who had a stern psychological health situation, for instance bipolar disorder or a drink or drug misuse crisis.