Forget Plastics, Mr. Robinson ? Supplements
In addition to having your person eat well, exercise regularly, abstain from smoking, and drink a little alcohol and a lot of green tea (or take resveratrol and EGCG supplements), you can command your person to acquire any number of nutritional supplements to compensate for the losses that time and age incur. Some such supplements are focused squarely on you?and that's where galantamine shines (it's a neural rust-fighter, remember?).
Galantamine, as you may recall, increases your acetylcholine levels by acting as an acetylcholinesterase inhibitor, thus enhancing the neurotransmissions that enable you to function properly. And, unlike other acetylcholinesterase inhibitors, galantamine acts as a modulator of your nicotinic receptors, helping both to protect them from degradation and to make them more receptive to acetylcholine molecules; both of these actions help to boost your acetylcholine activity, making you a healthier, sharper brain.
It seems highly likely that
galantamine will also prove to be
effective against MCI, a major
risk factor for dementia.
But, being a brain, you knew all that, right? Besides, we’ve gone into the technical stuff many times before, so let's just get to the bottom line: galantamine's dual mode of action on acetylcholine levels and activity has proven to be remarkably effective in slowing, halting, or even, sometimes, reversing the progress of Alzheimer's disease in mild to moderate cases (see “Galantamine Combats Alzheimer's and Vascular Dementia” in the November 2002 issue). It has even been shown recently that galantamine is effective in cases described as “advanced moderate” (see “Galantamine Works Even Better than Was Thought” in the April 2003 issue).
With Galantamine, the Earlier the Better
And here's what is really important: although clinical evidence for it is not yet at hand, it seems highly likely that galantamine will also prove to be effective against MCI, the “normal aging” condition that is a major risk factor for both Alzheimer's disease and vascular dementia, the other leading type of dementia (see “Galantamine May Help with Mild Cognitive Impairment” in the February 2003 issue).
If ever you wish to protect yourself, Brain, from the ravages of your own decline, it's best to start early. Truer words were never spoken than, “An ounce of prevention is worth a pound of cure.” By the time you have Alzheimer's disease or vascular dementia, serious damage has already been done, and even with galantamine, further damage is highly likely, albeit at a significantly slower pace than otherwise.
Insurance for Your Marbles
So, Brain, if you want to keep all your marbles (oh, that's right, you are the marbles) and you think you may be at risk, use the wisdom that God gave you, and consider seriously the protective, preventive use of galantamine as an insurance policy against dementia. Like all insurance, galantamine costs money, but on the other hand, it's not called “a gift from the gods” for nothing.
Galantamine provides a heralded dual-mode action for boosting cholinergic function: it inhibits the enzyme acetylcholinesterase, thereby boosting brain levels of acetylcholine, and it modulates the brain's nicotinic receptors so as to maintain their function. The recommended daily serving ranges from a low of 4 to 8 mg of galantamine to begin with to a maximum of 24 mg, depending on the individual's response.
For an added measure of benefit, it is a good idea to take choline, the precursor molecule to acetylcholine, as well as pantothenic acid (vitamin B5), an important cofactor for choline. Thus it is possible to cover all bases in providing the means to enhance the levels and effectiveness of your acetylcholine.
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