Brain Foods

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Ginkgo Biloba

Ginkgo Biloba


Ginkgo biloba is often refereed to as a "living fossil" because it is believed to be the world's oldest living species at about 200 million years old. The Ginkgo tree has been used in Traditional Chinese Medicine for over 4,000 years. Various parts of the Ginkgo tree were reportedly used in the treatment of respiratory ailments, to improve circulation, as a digestive aid, as a tonic for memory loss in the elderly and as a longevity elixir. In Germany, Ginkgo is a top-selling over- the-counter and prescription drug. Modern Ginkgo biloba extracts are produced from the leaves of cultivated trees and still enjoy a large audience for the treatment of various disorders. High quality Ginkgo biloba extract is normally standardized to 24% ginkgo flavone glycosides and 6% terpene lactones.


Improves memory / Mental sharpness
Alleviates symptoms of Alzheimer's Disease
Improves circulation
Thins blood / Cardiovascular health


The two groups of phytochemicals to which ginkgo biloba is normally standardized, ginkgo flavone glycosides and terpene lactones, are considered to be the primary active constituents. The flavone glycosides, which include quercetin, kaempherol and isorhamnetin, are responsible for the antioxidant properties of ginkgo biloba extract. The terpene lactones, which include ginkgolides A, B and C, as well as bilobalide, possess several activities. These activities include neuroprotection, improvement of choline (a neurotransmitter) uptake in brain synapses and inhibition of platelet activating factor (which reduces the tendency of the blood to clot).

Scientific Support

Laboratory and clinical studies have found a great deal of support for the majority of claims made for the therapeutic use of Ginkgo biloba extract. The German Commission E approves Ginkgo for effective therapy in cases of memory deficits, impaired concentration, depression, dizziness, tinnitus (ringing in the ears) or headache. The primary groups of dementias targeted for treatment with Ginkgo are primary degenerative dementia, vascular dementia and mixed forms of both. Ginkgo is also approved for use in the improvement of pain-free walking in those patients diagnosed with intermittent claudication or peripheral arterial occlusive disease (both are conditions in which improved circulation helps relieve symptoms). Lastly, the Commission E recommends Ginkgo for vertigo and tinnitus ? which also may be caused by inadequate circulation. A wide variety of clinical studies have been conducted on the benefits of Ginkgo biloba extract, many in Germany, but several in the USA. Major findings include:

Oxygen use (improvement of hypoxic (lack of oxygen) tolerance)
Brain circulation (inhibition / prevention of brain damage due to trauma and/or toxicity)
Eye health (protection of retina)
Neurotransmitter support (inhibits age-related loss of choline receptors and stimulates choline uptake in the hippocampus region of the brain)
Memory support (increased memory performance and learning capacity)
Systemic circulation (improvement of blood flow, particularly in microcirculation of capillaries)
Cardiovascular risk factor reduction (antioxidant effects, reduces activity of platelet activating factor ? reduces tendency of blood to clot)
General neuroprotective effects

A meta-analysis, published in the British Journal of Pharmacology, analyzed the quality of research conducted in over 40 clinical studies investigating Ginkgo biloba extract in the treatment of cerebral insufficiency. Cerebral insufficiency is associated with age-related mental decline or dementia. The resulting analysis concluded that the reviewed research was on par with research conducted on traditional prescription medications for treatment of dementia (including Alzheimer's) and that Ginkgo biloba extract is effective in reducing all symptoms of cerebral insufficiency, including impaired mental function. In a placebo-controlled, double-blind, randomized study, 72 patients with cerebral insufficiency (lack of blood flow to the brain) were subjected to a computerized test of short term memory. At the end of six weeks, the group receiving Ginkgo biloba extract exhibited a statistically significant improvement in short term memory capacity while the placebo group showed no significant increase. Clinical evidence indicates that Ginkgo biloba extract may be useful in the treatment of certain types of depression, notably "resistant" depression. At least one study correlated a reduction of cerebral blood flow in depressed patients. In one placebo-controlled study, patients who continued to exhibit symptoms of depression after the use of antidepressants were given 240 mg per day of Ginkgo biloba extract. The patients receiving Ginkgo biloba extract experienced a significant reduction in depressive symptoms as well as an improvement in cognitive function. In an open clinical trial of 60 patients having erectile dysfunction, 60mg of ginkgo per day, 50% of the patients regained potency and 25% showed improved arterial blood flow following 6 months of supplementation (5% showed no improvement). There has been some question as to the ability of Ginkgo biloba extract to improve cognitive function in healthy subjects (which is very difficult to measure). However, two recent studies of healthy volunteers measured brain activity using sensitive electroencephalography (EEG) and found that dosages of 120-240mg of Ginkgo biloba extract increase cognitive function (measured as alpha wave activity) within 30 minutes (peak measures were recorded 2-3 hours after consuming the supplements). The enhancement in alpha wave activity was similar to that achieved through the use of drugs that improve cognitive function. Both studies concluded that Ginkgo biloba extract improves cognitive function in healthy subjects.


Ginkgo biloba extract is, very rarely, associated with gastrointestinal upset, allergic skin reaction and headache. There are no known contraindications or interactions with other drugs. Ginkgo biloba is not known to be toxic at high dosages although its inhibition of platelet activating factor could pose a concern to those individuals with blood clotting problems or those taking anticoagulant medications (so check with your doctor before taking ginkgo biloba).


Ginkgo biloba is valuable for a broad array of health concerns related to problems with microcirculation ? whether they be in the brain, legs or sex organs. Ginkgo biloba's neuroprotective effects are also well established and its benefits in improving mental function and memory in healthy subjects looks promising.


The general consensus is that for the treatment of microcirculation problems in the extremities, including vertigo, tinnitus and intermittent claudication, a dosage of 120-160 mg per day is suitable. For treatment of dementia, mild depression, and improvement of cognitive abilities, higher doses (about 240 mg/day) are recommended. For best results, daily dosage is typically split into 2-3 divided doses. Be sure to look for an extract standardized to at least 24% ginkgo flavone glycosides and 6% terpene lactones ? because this is the type of extract that has been shown to be effective in virtually every clinical trial.


  1. Agnoli A, Fiorani P, Pistolese GR. Preliminary results in the modifications of cerebral blood flow using xenon-133 during administration of ginkgo-biloba. Minerva Med. 1973 Nov 7;64(79 Suppl):4166-73.
  2. Allard M. Treatment of the disorders of aging with Ginkgo biloba extract. From pharmacology to clinical medicine. Presse Med. 1986 Sep 25;15(31):1540-5.
  3. al-Zuhair H, Abd el-Fattah A, el-Sayed MI. The effect of meclofenoxate with ginkgo biloba extract or zinc on lipid peroxide, some free radical scavengers and the cardiovascular system of aged rats. Pharmacol Res. 1998 Jul;38(1):65-72.
  4. Christen Y. Oxidative stress and Alzheimer disease. Am J Clin Nutr. 2000 Feb;71(2):621S-629S.
  5. Deberdt W. Interaction between psychological and pharmacological treatment in cognitive impairment. Life Sci. 1994;55(25-26):2057-66.
  6. Diamond BJ, Shiflett SC, Feiwel N, Matheis RJ, Noskin O, Richards JA, Schoenberger NE. Ginkgo biloba extract: mechanisms and clinical indications. Arch Phys Med Rehabil. 2000 May;81(5):668-78.
  7. Fowler JS, Wang GJ, Volkow ND, Logan J, Franceschi D, Franceschi M, MacGregor R, Shea C, Garza V, Liu N, Ding YS. Evidence that gingko biloba extract does not inhibit MAO A and B in living human brain. Life Sci. 2000 Jan 21;66(9):PL141-6.
  8. Garg RK, Nag D, Agrawal A. A double blind placebo controlled trial of ginkgo biloba extract in acute cerebral ischaemia. J Assoc Physicians India. 1995 Nov;43(11):760-3.
  9. Gsell W, Reichert N, Youdim MB, Riederer P. Interaction of neuroprotective substances with human brain superoxide dismutase. An in vitro study. J Neural Transm Suppl. 1995;45:271-9.
  10. Hannequin D, Thibert A, Vaschalde Y. Development of a model to study the anti-edema properties of Ginkgo biloba extract. Presse Med. 1986 Sep 25;15(31):1575-6.
  11. Heiss WD. Pharmacologic modification of the circulation in the brain. Bull Schweiz Akad Med Wiss. 1980 Apr;36(1-3):183-207.
  12. Heiss WD. Therapy of cerebral ischemia. Z Kardiol. 1987;76 Suppl 4:87-98.
  13. Hemmer R, Tzavellas O. On cerebral effect of plant preparation from Ginkgo biloba. Arzneimittelforschung. 1967 Apr;17(4):491-3.
  14. Hofferberth B. The effect of Ginkgo biloba extract on neurophysiological and psychometric measurement results in patients with psychotic organic brain syndrome. A double-blind study against placebo. Arzneimittelforschung. 1989 Aug;39(8):918-22.
  15. Hoyer S. Possibilities and limits of therapy of cognition disorders in the elderly. Z Gerontol Geriatr. 1995 Nov-Dec;28(6):457-62.
  16. Itil TM, Eralp E, Ahmed I, Kunitz A, Itil KZ. The pharmacological effects of ginkgo biloba, a plant extract, on the brain of dementia patients in comparison with tacrine. Psychopharmacol Bull. 1998;34(3):391-7.
  17. Ivaniv OP. The results of using different forms of a Ginkgo biloba extract (EGb 761) in the combined treatment of patients with circulatory encephalopathy. Lik Sprava. 1998 Dec;(8):123-8.
  18. Khalsa DS. Integrated medicine and the prevention and reversal of memory loss. Altern Ther Health Med. 1998 Nov;4(6):38-43.
  19. Kidd PM. A review of nutrients and botanicals in the integrative management of cognitive dysfunction. Altern Med Rev. 1999 Jun;4(3):144-61.
  20. Kleijnen J, Knipschild P. Ginkgo biloba. Lancet. 1992 Nov 7;340(8828):1136-9.
  21. Koltringer P, Eber O, Klima G, Rothlauer W, Wakonig P, Langsteger W, Lind P. Microcirculation in parenteral Ginkgo biloba extract therapy. Wien Klin Wochenschr. 1989 Mar 17;101(6):198-200.
  22. Kunkel H. EEG profile of three different extractions of Ginkgo biloba. Neuropsychobiology. 1993;27(1):40-5.
  23. Massoni G, Piovella C, Fratti L. Effects on microcirculation of Ginkgo-biloba in elderly people. G Gerontol. 1972 May;20(5):444-50.
  24. Perry EK, Pickering AT, Wang WW, Houghton P, Perry NS. Medicinal plants and Alzheimer's disease: Integrating ethnobotanical and contemporary scientific evidence. J Altern Complement Med. 1998 Winter;4(4):419-28.
  25. Perry EK, Pickering AT, Wang WW, Houghton PJ, Perry NS. Medicinal plants and Alzheimer's disease: from ethnobotany to phytotherapy. J Pharm Pharmacol. 1999 May;51(5):527-34.
  26. Pidoux B. Effects of Ginkgo biloba extract on functional brain activity.. An assessment of clinical and experimental studies. Presse Med. 1986 Sep 25;15(31):1588-91.
  27. Pitchumoni SS, Doraiswamy PM. Current status of antioxidant therapy for Alzheimer's Disease. J Am Geriatr Soc. 1998 Dec;46(12):1566-72.
  28. Pospelova ML, Barnaulov OD. The antihypoxic and antioxidant action of medicinal plants as the basis for their use in destructive brain diseases. Fiziol Cheloveka. 2000 Jan-Feb;26(1):100-6.
  29. Raabe A, Raabe M, Ihm P. Therapeutic follow-up using automatic perimetry in chronic cerebroretinal ischemia in elderly patients. Prospective double-blind study with graduated dose ginkgo biloba treatment. Klin Monatsbl Augenheilkd. 1991 Dec;199(6):432-8.
  30. Racagni G, Brunello N, Paoletti R. Neuromediator changes during cerebral aging. The effect of Ginkgo biloba extract. Presse Med. 1986 Sep 25;15(31):1488-90.
  31. Ramassamy C, Averill D, Beffert U, Bastianetto S, Theroux L, Lussier-Cacan S, Cohn JS, Christen Y, Davignon J, Quirion R, Poirier J. Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype. Free Radic Biol Med. 1999 Sep;27(5-6):544-53.
  32. Reisecker F. Therapy approaches in cerebral cognitive deficits--neuropsychiatric aspects. Wien Med Wochenschr. 1996;146(21-22):546-8.
  33. Saponaro A. Modifications of the rheogram of cranial retinal vessels following administration of ginkgo-biloba. Minerva Med. 1973 Nov 7;64(79 Suppl):4194-8.
  34. Sastre J, Pallardo FV, Garcia de la Asuncion J, Vina J. Mitochondria, oxidative stress and aging. Free Radic Res. 2000 Mar;32(3):189-98.
  35. Semlitsch HV, Anderer P, Saletu B, Binder GA, Decker KA. Cognitive psychophysiology in nootropic drug research: effects of Ginkgo biloba on event-related potentials (P300) in age-associated memory impairment. Pharmacopsychiatry. 1995 Jul;28(4):134-42.
  36. Spinnewyn B, Blavet N, Clostre F. Effects of Ginkgo biloba extract on a cerebral ischemia model in gerbils. Presse Med. 1986 Sep 25;15(31):1511-5.
  37. Taillandier J, Ammar A, Rabourdin JP, Ribeyre JP, Pichon J, Niddam S, Pierart H. Treatment of cerebral aging disorders with Ginkgo biloba extract. A longitudinal multicenter double-blind drug vs. placebo study. Presse Med. 1986 Sep 25;15(31):1583-7.

38. Warburton DM. Clinical psychopharmacology of Ginkgo biloba extract. Presse Med. 1986 Sep 25;15(31):1595-604. 39. Winter JC. The effects of an extract of Ginkgo biloba, EGb 761, on cognitive behavior and longevity in the rat. Physiol Behav. 1998 Feb 1;63(3):425-33.

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