Piracetam is the best known nootropic drug
It's mechanism of action is unknown but most would describe it as facilitating learning in ways that are hard to quantify. It seems to awaken a noticible improvement in creativity and lucidity, but it is not a simulant or sedative.
The scientific record on piracetam is quite extensive.It does not seem to be metabolized by the body, and it's effect is minimal on the dopaminergic and serotonergic neurotransmitter systems. It does seem to lower acetylcholine levels slightly.This decline is reversed when choline is given with piracetam. (Many people report that choline potentiates piracetam.)
Piracetam also seems to have neuroprotective properties, for example, it seems to block the action of some sedative drugs. This action is fairly easy to measure and has been studied extensively.Research on piracetam has been controversial. Piracetam has been found to be particularly useful in alcohol withdrawal and in treating age-related mental decline and some forms of drug-resistant depression.It is inexpensive and available over-the-counter in Mexico.Although it has virtually no toxicity and it's benefits are well documented, it is not available in the US. Steven Fowlkes has a fairly good work up on obtaining piracetam and other smart drugs in Mexico on his excellent
Piracetam has been proven to boost learning and memory in normal subjects as well as those who suffer cognitive deficits, and is also a cognitive enhancer under conditions of hypoxia or too little oxygen. Recent expeditions to climb Mt. Everest have included piracetam as an essential medication to treat frostbite and memory lapses causes by altitude.
In fact it selectively stimulates the anterior or frontal part of the forebrain, that part of the brain that has evolved most recently rapidly and remarkably in the course of our evolution from ape to human and which is the seat of our higher functions.
It also seems to enhance some forms of protein syntheses in the brain.It's been proven that protein synthesis is an essential step in laying down long-term memories.
Perhaps the most intriguing aspect of piracetam is that it has been proven to increase the flow of information between the right and left hemispheres of the brain.
As a result of experiments with human subjects one researcher concluded that piracetam causes the hemispheres to become superconnected.
Since there's increasing evidence that high level brain states are a product of the integrated and synergistic functioning of both hemispheres simultaneously we might suspect that piracetam enhances not only simple learning and memory but creative or syntheses thinking.
Piracetam's capacity to superconnect the hemispheres becomes even more intriguing in light of the evidence indicating that many of the most widely used mind machines and techniques for brain enhancement such as binaural beat frequencies and the sound and light machines function in part by facilitating integrated hemispheric functioning.
One theory is that since both the machines and piracetam seem to facilitate interhemispheric communication there might be a potentiating or synergistic effect when such mind machines are used in combination with piracetam resulting in a potentiation in brain enhancement effects.
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