Vitamin B12 and diseases
Neural-Tube Defects (NTD):
Both genetic and environmental factors are implicated in the pathogenesis of NTD; these include maternal folate deficiency, maternal cobalamin deficiency, and hyperhomocysteinemia. Findings suggest vitamin B12 status to be an independent risk factor for NTD.
Case reports and studies over many years have attributed psychotic symptoms to cobalamin deficiency. Several cases demonstrated a resolution of symptoms after administration of cobalamin. Further study is needed to refine the detection and clinical management of cobalamin deficiency in the psychiatric population.
Researchers at the University of Georgia studied 55 healthy women, aged 60 to 71 years. It was found that serum concentration of folic acid and vitamin B12 were more than 30% lower among hearing-impaired women than among those with normal hearing. When auditory function was divided into three categories: excellent, good, and impaired. A dose-response association between age-related hearing loss relation was observed for red cell folate and serum concentrations of vitamin B12 and folic acid. These findings and vitamin B12 and folic acid nutritional status suggest that inadequate dietary intake if these nutrients may increase risk of hearing loss.
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