Medical Dictionary

Medical Dictionary

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senile plaque

Characteristic feature of the brains of Alzheimer's patients and aged monkeys, consisting of a core of amyloid fibrils surrounded by dystrophic neurites.
The principal component of amyloid fibrils in senile plaques is B/A4, a peptide of about 4 kD that is derived from the larger amyloid precursor protein (APP). The B/A4 sequence is located near the C terminus of APP.

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