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A promising methodological approach of optogenetics is the combination with functional Magnetic Resonance Imaging (fMRI).

This combination has been termed “opto-fMRI” or “ofMRI” (Desai et al., 2011; Deisseroth, 2012), and has been applied to several domains (Desai et al., 2011; Abe et al., 2012).

Although still facing some challenges (Christie et al., 2012), the combination of fMRI with optogenetics provides a unique possibility to observe how functional changes in the brain are brought about as a result of optogenetic manipulation.

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