Fibromatosis is a condition where fibrous overgrowths of dermal and subcutaneous connective tissue develop tumours called fibromas. These fibromas are usually benign (non-cancerous).
There appears to be many different ways to classify fibromatosis. One classification system used is based on age (i.e.: juvenile vs adult fibromatoses) and localisation (i.e.: superficial vs deep fibromatoses).
- Slow growing tumour
- Small size
- Arise from fascia or aponeurosis
- Less aggressive
- Rapidly growing tumour
- Usually reach large size
- Often involve deeper structures (muscles of the trunk and extremities)
Whilst most fibromatoses are benign tumours and do not metastasise (spread to other parts of the body), the desmoid tumours although they do not metastasise like malignant cancers can be locally aggressive. They can grow quickly into large tumours that can obstruct vital structures such as major blood vessels, nerves and organs.
The cause of fibromatosis remains unclear. In some types of fibromatosis such as desmoid tumours it is thought that the condition may be related to trauma, hormonal factors, or have a genetic association. Superficial fibromatoses such as palmar, plantar and penile fibromatosis have sometimes been linked to certain diseases such as diabetes, liver disease and hypertension.
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