Skin Diseases

Skin Diseases

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Wegener's Granulomatosis

Wegener's granulomatosis (WG) is a systemic vasculitis, defined by a clinical triad of manifestations that includes involvement of the upper airways, lungs, and kidneys and by a pathologic triad consisting of necrotizing granulomas in the upper respiratory tract and lungs, vasculitis involving both arteries and veins, and glomerulitis.

Causes:

Immunopathogenesis unclear. Possibly an aberrant hypersensitivity response to an exogenous or endogenous antigen that enters through or resides in upper airways. Clinical symptomatology caused by necrotizing vasculitis of small arteries and veins. Pulmonary involvement: multiple, bilateral, nodular infiltrates. Similar infiltrates in paranasal sinuses, nasopharynx.

Symptoms:

* voice change
* hoarseness
* shortness of breath
* cough
* Weakness
* Bloody sputum
* Wheezing
* Chest pain
* Rashes
* Joint pains

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