Coccidioidomycosis is a systemic mycosis characterized by primary pulmonary infection that usually spontaneously. Subsequently, It can disseminate hematogenously and result in chronic, progressive, granulomatous infection in skin, lungs, bone, meninges.
Spores inhaled, resulting in primary pulmonary infection that is asymptomatic or accompanied by symptoms of coryza. Failure to develop cellmediated immunity is associated with disseminated infection and relapse after therapy.
Symptoms include fever, joint pain, loss of appetite, weight loss, night sweats, skin lesions, and difficulty breathing. Also, in 30-50% of patients with disseminated coccidioidomycosis, the tissue coverings of the the brain and spinal cord become inflamed (meningitis).
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