Skin Diseases

Skin Diseases

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Lymphomatoid Papulosis

Lymphomatoid papulosis is a stubborn persistent rash that usually occurs on the chest, stomach, back, arms and legs.

Lymphomatoid papulosis is an asymptomatic, chronic, self-healing, polymorphous eruption characterized by recurrent crops of lesions that regress spontaneously, with histologic features of lymphocytic atypia. It is a low-grade, self-limited T cell lymphoma with a low but real risk of progression to more malignant forms of lymphoma.


Causes:

Unknown; considered to be a low-grade lymphoma controlled by host mechanisms without systemic involvement. Antigens shared with and occasional progression to Hodgkin's disease or cutaneous T cell lymphoma suggest a low-grade lymphoma, perhaps induced by chronic antigenic stimulation. Lymphomatoid papulosis may begin as a chronic, reactive, polyclonal lymphoproliferative phenomenon that sporadically overwhelms host immune defenses and evolves into a clonal, antigen-independent, true lymphoid malignancy. Belongs in the spectrum of primary cutaneous Ki-1 + lymphoproliferative disorders, including pseudo-Hodgkin's disease of the skin, regressing atypical histiocytosis, Hodgkin's lymphoma, and Ki-1 + large cell lymphoma.


Symptoms:

Most patients present with multiple skin papules (raised bumps) that may occur anywhere on the body but most often affect the chest, stomach, back, arms and legs. The papules appear in crops and may be mildly itchy. They may develop into blood or pus-filled blisters that break and form a crusty sore before healing completely. Lesions spontaneously heal with or without scarring within 2-8 weeks of appearing.

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