Skin Diseases

Skin Diseases

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Langerhans Cell Histiocytosis

Langerhans cell histiocytosis (LCH) is an idiopathic group of disorders characterized histologically by proliferation and infiltration of tissue by Langerhans cell-type histiocytes that fuse into multinucleated giant cells and form granulomas with eosinophils. LCH is characterized clinically by cutaneous findings that range from soft tissue swelling to eczema-like and seborrheic dermatitis-like changes and ulceration and by lytic bony lesions.


The stimulus for the proliferation of Langerhans cells is unknown.


*A painful lump on a bone
*Delayed puberty
*Bone pain
*Increased eyeball protrusion
*Generalized rash (petechiae or purpura)
*Chronically draining ears

The symptom underlying all of these signs are histiocytic lesions on skin, bones, lung, liver, spleen, gums, ears, eyes, and/or the central nervous system.

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