A potentially life-threatening disease of unknown etiology occurring more often in females than males and manifesting mainly in skin and the central nervous system.
The condition develops slowly over a variable time frame. Non-specific prodromal symptoms (headache, dizziness) often precede livedo reticularis by several years and this is followed by the development of focal neurological symptoms and then progressive cognitive impairment. Involvement of fundi, peripheral nerves, heart, and kidneys is frequent but usually asymptomatic. Livedo reticularis is a bluish mottling of skin, usually on the legs, and the appearance may be aggravated by exposure to cold.
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