Lymphogranuloma venereum (LGV) is an STD caused by Chlamydia trachomatis. Acute LGV in heterosexual men is characterized by a transient primary genital lesion followed by multilocular suppurative regional lymphadenopathy. Women, homosexual men, andin occasional instances-heterosexual men may develop hemorrhagic proctitis with regional lymphadenitis. After a latent period of years, late complications include genital elephantiasis due to lymphatic involvement; strictures; and fistulas of penis, urethra, rectum.
Primarily an infection of lymphatics and lymph nodes. Lymphangitis and lymphadenitis occur in drainage field of the inoculation site with subsequent perilymphangitis and periadenitis. Necrosis occurs and loculated abscesses, fistulas, and sinus tracts develop. As the infection subsides, fibrosis replaces acute inflammation with resulting obliteration of lymphatic drainage, chronic edema, and stricture. Inoculation site determines affected lymph nodes: penis, anterior urethra-superficial, deep inguinal; posterior urethra-deep iliac, perirectal; vulva-inguinal; vagina, cervix-deep iliac, perirectal, retrocrural, lumbosacral; anus-inguinal; rectum-perirectal, deep iliac.
* Swelling and redness of the skin over the inguinal lymph nodes
* Drainage from inguinal lymph nodes
* Drainage of blood or pus from the rectum
* Ulcerates, heals and disappears within a few days and may go unnoticed.
* Chronic infection may result in severe scarring causing major deformation of the genitals.
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